First product:
DermaFC
Dermatofluoroscopy is a method for the early detection of malignant melanoma.
This patented technology is based on the selective excitation of melanin fluorescence in the skin. The skin lesion suspicious of malignant melanoma is scanned with the laser and Magnosco’s machine learning algorithm analyzes the data and provides a score that guides the physician to a reliable diagnosis. The Magnosco DermaFC, in which the method has applications, is in use for study purposes only.
Dermatofluoroscopy
Under normal excitation conditions, the ultra-weak melanin fluorescence is completely outshone by the autofluorescence of other endogenous fluorophores in the skin such as NADH, tryptophan, flavin, or lipofuscin. Using stepwise two-photon absorption, melanin can be selectively excited and its fluorescence becomes visible.
In dermatofluoroscopy, melanocytes of healthy skin, melanocytes of nevi, and melanocytes of melanomas show characteristic fluorescence spectra that allow reliable differentiation between benign and malignant tissue.
For the excitation of melanin by stepwise two-photon absorption, nanosecond laser pulses are focused at 800 nm in the epidermis. The resulting melanin fluorescence is detected in the range of approximately 385 – 785 nm. Using this excitation technique, the lesion is scanned point by point.
